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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1A3
All Species:
1.21
Human Site:
S269
Identified Species:
2.22
UniProt:
Q02108
Number Species:
12
Phosphosite Substitution
Charge Score:
-0.08
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02108
NP_000847.2
690
77452
S269
T
K
P
S
L
S
P
S
K
P
Q
S
S
L
V
Chimpanzee
Pan troglodytes
XP_522169
734
81883
P308
T
N
I
M
K
N
L
P
Q
G
T
S
Q
V
P
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_536590
746
83063
A320
T
T
I
T
K
N
L
A
Q
G
T
S
H
V
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9ERL9
691
77555
G269
T
K
P
S
L
S
P
G
K
P
Q
S
S
L
V
Rat
Rattus norvegicus
P19686
690
77548
G268
T
K
P
S
L
S
P
G
K
P
Q
S
S
L
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510214
690
77963
C269
T
K
P
S
L
S
P
C
K
P
Q
S
S
L
V
Chicken
Gallus gallus
XP_420375
688
77848
C267
A
K
P
S
L
S
P
C
K
P
Q
S
S
L
V
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_002667138
626
69572
Q251
A
A
A
R
R
I
Y
Q
S
E
V
S
V
E
E
Tiger Blowfish
Takifugu rubipres
NP_001027855
675
75480
P275
A
K
S
L
S
P
S
P
L
R
A
T
S
A
G
Fruit Fly
Dros. melanogaster
Q07093
676
75644
N262
N
A
S
D
L
Q
M
N
S
S
S
F
C
K
M
Honey Bee
Apis mellifera
NP_001011650
699
78655
S278
T
S
L
F
R
P
L
S
S
E
A
T
D
L
R
Nematode Worm
Caenorhab. elegans
O02298
688
78384
K279
P
F
S
Y
E
S
I
K
Y
Y
K
N
S
L
F
Sea Urchin
Strong. purpuratus
P16065
1125
126238
A513
N
W
A
L
Y
L
G
A
S
I
P
T
F
L
I
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
47.9
N.A.
47.3
N.A.
89.5
89.2
N.A.
87.5
84
N.A.
39.1
58.9
34.2
35
29.5
22.6
Protein Similarity:
100
63
N.A.
62.4
N.A.
94.9
94.9
N.A.
93.4
92.3
N.A.
54.3
73.6
53.3
55.3
48.2
36.3
P-Site Identity:
100
13.3
N.A.
13.3
N.A.
93.3
93.3
N.A.
93.3
86.6
N.A.
6.6
13.3
6.6
20
20
6.6
P-Site Similarity:
100
33.3
N.A.
46.6
N.A.
93.3
93.3
N.A.
93.3
86.6
N.A.
6.6
20
20
26.6
33.3
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
24
16
16
0
0
0
0
16
0
0
16
0
0
8
0
% A
% Cys:
0
0
0
0
0
0
0
16
0
0
0
0
8
0
0
% C
% Asp:
0
0
0
8
0
0
0
0
0
0
0
0
8
0
0
% D
% Glu:
0
0
0
0
8
0
0
0
0
16
0
0
0
8
8
% E
% Phe:
0
8
0
8
0
0
0
0
0
0
0
8
8
0
8
% F
% Gly:
0
0
0
0
0
0
8
16
0
16
0
0
0
0
8
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
16
0
0
8
8
0
0
8
0
0
0
0
8
% I
% Lys:
0
47
0
0
16
0
0
8
39
0
8
0
0
8
0
% K
% Leu:
0
0
8
16
47
8
24
0
8
0
0
0
0
62
0
% L
% Met:
0
0
0
8
0
0
8
0
0
0
0
0
0
0
8
% M
% Asn:
16
8
0
0
0
16
0
8
0
0
0
8
0
0
0
% N
% Pro:
8
0
39
0
0
16
39
16
0
39
8
0
0
0
16
% P
% Gln:
0
0
0
0
0
8
0
8
16
0
39
0
8
0
0
% Q
% Arg:
0
0
0
8
16
0
0
0
0
8
0
0
0
0
8
% R
% Ser:
0
8
24
39
8
47
8
16
31
8
8
62
54
0
0
% S
% Thr:
54
8
0
8
0
0
0
0
0
0
16
24
0
0
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
8
0
8
16
39
% V
% Trp:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
8
8
0
8
0
8
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _